Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation
نویسندگان
چکیده
منابع مشابه
In-vivo imaging of changes in abdominal aortic aneurysm thrombus volume during the cardiac cycle.
PURPOSE To evaluate in-vivo thrombus compressibility in abdominal aortic aneurysms (AAAs) to hopefully shed light on the biomechanical importance of intraluminal thrombus. METHODS Dynamic electrocardiographically-gated computed tomographic angiography was performed in 17 AAA patients (15 men; mean age 73 years, range 69-76): 11 scheduled for surgical repair and 6 under routine surveillance. T...
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BACKGROUND Angiotensin II (ANG II) promotes vascular inflammation and induces abdominal aortic aneurysm (AAA) in hyperlipidemic apolipoprotein E knock-out (apoE(-/-)) mice. The aim of the present study was to detect macrophage activities in an ANG II-induced early-stage AAA model using superparamagnetic iron oxide (SPIO) as a marker. METHODOLOGY/PRINCIPAL FINDINGS Twenty-six male apoE(-/-) mi...
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BACKGROUND Degradation of extracellular matrix support in the large abdominal arteries contribute to abnormal dilation of aorta, leading to abdominal aortic aneurysms, and matrix metalloproteinase-9 (MMP-9) is the predominant enzyme targeting elastin and collagen present in the walls of the abdominal aorta. Previous studies have suggested a potential association between MMP-9 genotype and abdom...
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Current laboratory research in the field of abdominal aortic aneurysm (AAA) disease often utilizes small animal experimental models induced by genetic manipulation or chemical application. This has led to the use and development of multiple high-resolution molecular imaging modalities capable of tracking disease progression, quantifying the role of inflammation, and evaluating the effects of po...
متن کاملChanges in Vessel Properties During Early Progression of Murine Abdominal Aortic Aneurysms from In Vivo Ultrasound
Abdominal aortic aneurysms (AAA) are a common and frequently fatal disease characterized by the weakening and dilation of the aorta. The larger the aneurysm, the higher the chances are of rupturing and life-threatening hemorrhage. The aim of this study is to apply the angiotensin II (AngII) model of AAAs in male apolipoprotein-Edeficient mice (apoE C57Bl/6J), in order to analyze, quantify, and ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2019
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvz178